What’s Really Making Us Fat? Carbs? Sugar? (Joe Rogan Response) ft. Stephan Guyenet

What’s Really Making Us Fat? Carbs? Sugar? (Joe Rogan Response) ft. Stephan Guyenet

In this video I’m speaking with Dr. Stephan Guyenet about the science behind what is driving fat gain. We also cover the “is a calorie a calorie” question, address the role of sugar/carbs in obesity and diabetes and the role of the brain in regulating all of this.

This interview was recorded just after the debate on the Joe Rogan Experience Podcast (JRE) between Gary Taubes and Stephan Guyenet, which you can listen to here:


0:00 – Intro and topics summary
1:44 – Joe Rogan’s podcast has a negative bias toward carbs
3:54 – Cliffs notes summary of Gary Taubes and Stephan’s positions
7:25 – Is Gary’s or Stephan’s model the “mainstream” scientific model of weight gain?
12:20 – Is the calories in/calories out (CICO) model of weight gain correct?
17:02 – Is tracking calories or “eating less and moving more” the best way to implement weight loss?
23:22 – What does the science say about calories in/calories out?
28:54 – “Is a calorie a calorie?” discussion
38:22 – Why do some people gain fat more easily than others?
45:27 – Is there anything “different” about the brains of obese people?
47:06 – What is the role of sugar in driving fat gain, obesity and diabetes?
58:53 – Is sugar addictive?
1:03:39 – What are the practical takeaways for avoiding obesity or losing weight?

You can also listen on The Jeff Nippard Podcast on iTunes and Stitcher


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Stephan’s Website:

Stephan’s debate reference list (everything we discuss can be found in here)

Stephan’s Diet Book Reviews:


The Hall Meta-Analysis (Calorie A Calorie Study):

My video on sugar 1:

My response to criticisms on sugar (vid 2):

Outro Music:
‣ Ryan Little:


About me: I’m a Canadian natural pro bodybuilder and internationally-qualified powerlifter with a BSc in biochemistry/chemistry and a passion for science. I’ve been training for 12 years drug-free. I’m 5’5 and fluctuate between 160 lbs (lean) and 180 lbs (bulked).


Disclaimers: Jeff Nippard is not a doctor or a medical professional. Always consult a physician before starting any exercise program. Use of this information is strictly at your own risk. Jeff Nippard will not assume any liability for direct or indirect losses or damages that may result from the use of information contained in this video including but not limited to economic loss, injury, illness or death.

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